Sedating pain

Most of the trials were short at just one or two nights' duration, involved only a small number of patients and used poorly described methodology.

Therefore it was difficult to find out the exact effects of these drugs on patients with as measured by the numbers and duration of pauses in breathing during sleep.

In small, single-night studies, zolpidem 20 mg, flurazepam 20 mg and triazolam 0.25 mg showed a tendency to increase numbers and duration of pauses during sleep, which was not as measured by the numbers and duration of pauses in breathing during sleep, but significant clinical and statistical decreases in minimum oxygen levels during the night were observed with remifentanil, zolpidem and triazolam; therefore prescribing these drugs for patients with (remifentanil); some studies included CPAP treatment, whilst in a significant number of participants, previous treatment with CPAP was not stated and thus a residual treatment effect of CPAP could not be excluded.

Most studies were small and of short duration, with indiscernible methodological quality.

Trials were small, with only two trials, which used sodium oxybate, recruiting more than 40 participants, and all but three trials were of only one to three nights in duration.

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